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The oxymorphone in OPANA ER might lead to spasm on the sphincter of Oddi. Opioids could trigger boosts in serum amylase. Regularly Appraise clients with biliary tract ailment, which include acute pancreatitis, for worsening signs or symptoms.To reduce the risk of respiratory despair, suitable dosing and titration of OPANA ER are necessary [see DOSA